Bane
n.
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That which destroys life, esp. poison of a deadly quality. [Obs. except in combination, as in ratsbane, henbane, etc.]
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Destruction; death. [Obs.]
The cup of deception spiced and tempered to their bane.
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Any cause of ruin, or lasting injury; harm; woe.
Money, thou bane of bliss, and source of woe.
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A disease in sheep, commonly termed the rot.