Entry 1 sense Webster, 1913 cytoskeletal /(sī`tō̇*skĕl"ĕ*tal)/ · cy·to·skel·e·tal · IPA 01 a. Of or pertaining to the cytoskeleton; as, cytoskeletal microtubules. 1. Of or pertaining to the cytoskeleton; as, cytoskeletal microtubules.(Cell Biology)