Entry 2 senses · 2 variants Webster, 1913 Prodigalize · Prod·i·gal·ize · IPA v. i. v. t. 01 v. i. To act as a prodigal; to spend liberally. 1. To act as a prodigal; to spend liberally. 02 v. t. To expend lavishly. 1. To expend lavishly.