Entry 1 sense Webster, 1913 Staphylomatous /(stăf`ĭ*lō"mȧ*tŭs)/ · Staph·y·lo·ma·tous · IPA 01 a. Of or pertaining to staphyloma; affected with staphyloma. 1. Of or pertaining to staphyloma; affected with staphyloma.(Med.)