Entry 1 sense Webster, 1913 Sterilization /stĕrˌ-əl-əz-āsh'-ən/ · Ster·il·i·za·tion · IPA /stˌɛrələzˈeɪʃən/ 01 n. The act or process of sterilizing, or rendering sterile; also, the state of being sterile. 1. The act or process of sterilizing, or rendering sterile; also, the state of being sterile.(Biol.)