Entry 2 senses Webster, 1913 Synergistic /sĭnˌ-ẽrj-ĭs'-tĭk/ · Syn·er·gis·tic · IPA /sˌɪnərdʒˈɪstɪk/ 01 a. Of or pertaining to synergism. 1. Of or pertaining to synergism. 2. Cooperating; synergetic.