Entry 2 senses Webster, 1913 Synthesize /sĭn'-thəs-īzˌ/ · Syn·the·size · IPA /ˈsɪnθəsaɪz/ 01 v. t. To combine by synthesis; to unite. 1. To combine by synthesis; to unite. 2. To produce by synthesis; as, to synthesize albumin.