Grief /(grēf)/

Grief

n.
  1. Pain of mind on account of something in the past; mental suffering arising from any cause, as misfortune, loss of friends, misconduct of one's self or others, etc.; sorrow; sadness.
    The mother was so afflicted at the loss of a fine boy, . . . that she died for grief of it.
  2. Cause of sorrow or pain; that which afficts or distresses; trial; grievance.
    Be factious for redress of all these griefs.
  3. Physical pain, or a cause of it; malady. [R.]
    This grief (cancerous ulcers) hastened the end of that famous mathematician, Mr. Harriot.
    — Wood.

Phrases & Compounds

To come to grief
to meet with calamity, accident, defeat, ruin, etc., causing grief; to turn out badly.